Characterization of chronic aortic and mitral regurgitation using echocardiography and cardiovascular magnetic resonance

Introduction Grading of chronic aortic (AR) and mitral regurgitation (MR) severity can be obtained by echocardiography and cardiovascular magnetic resonance (CMR). The aims of the four studies were: (1) to establish echocardiographic thresholds for left ventricular (LV) dimensions indicating severe chronic AR or MR, using CMR as reference, (2) to elucidate the main cause of echocardiographic underestimation of LV dimensions compared with CMR, (3) to systematically compare three indirect CMR MR quantification methods (‘standard’, ‘volumetric’ and ‘flow’ method), as well as (4) to establish CMRand quantification method-specific thresholds indicating hemodynamically significant chronic AR or MR benefiting from surgery. Methods The first prospective study comprised a total of 93 (AR (n=44), MR (n=49)), the second 45 (healthy volunteers (n=20), AR (n=17), MR (n=8)), the third 52 (healthy volunteers (n=16), MR (n=36)) and the fourth 78 participants (AR (n=38), MR (n=40)). Two-dimensional (2DE) and real-time three-dimensional echocardiography (RT3DE) as well as CMR was performed in all participants. Operated patients with severe AR/MR, according to 2DE, underwent also post-surgical scans. Furthermore, a multimodality phantom model was investigated. Results (1) Linear dimensions could not sufficiently identify severe LV dilatation, in contrast to 2DE volumes, which showed an excellent (AR) or good (MR) diagnostic ability. The diagnostic ability was less powerful for RT3DE volumes. (2) All modalities delineated the phantom model with high precision. In vivo, 2DE/RT3DE underestimated LV short-axis end-diastolic linear, areal and all volumetric dimensions significantly compared with CMR, but not short-axis endsystolic linear and areal dimensions. (3) The ‘standard’ method determined significantly larger regurgitant volumes (RV) and fractions (RF), in contrast to the ‘volumetric’ and ‘flow’ method, which determined similar results. This affected the grading of severity in operated MR patients. (4) In operated patients, application of current RF thresholds by CMR led to frequent downgrading compared with 2DE. Furthermore, CMRand quantification method-specific thresholds were established, which were lower than recognized guideline criteria. Conclusions (1) LV volumes obtained by 2DE/RT3DE can support the diagnosis of severe AR and MR, when other causes of LV dilation have been considered. (2) Echocardiographic underestimation of LV dimensions is mainly due to inherent technical differences in the ability to differentiate trabeculated from compact myocardium. (3) The choice of indirect CMR MR quantification method can affect the grading of regurgitation severity and thereby eventually the clinical decisionmaking. (4) CMR grading of chronic AR and MR severity should be based on modalityand quantification method-specific thresholds to assure appropriate clinical decision-making.